This study was performed to identify and compare the pregnancy rates of simultaneous program of natural cycle in vitro fertilization(IVF) and cryopreserved-thawed embryo transfer (ET), NICE, with those of natural cycle in vitro fertilization(IVF)
and
cryopreserved-thawed embryo transfer(ET), respectively, Spontaneously ovulatory women(N=36) without male factor who had previously undergone IVF with embryo cryopreservation comprised the study NICE group. Spontaneously ovulatory women without
male
factor who had undergone natural cycle IVF(N45) or cryopreserved-thawed ET(N=29) in the study period served as the control proups.
In NICE group, 9 of the 47 initiated cycles were cancelled before ET, Thirty-eight ETs resulted in 13 clinical(34.2%) and 10 delivered(26.3%) pregnancies. In natural cycle IVF group, 19 of the 80 initiated cycles were cancelledbefore ET.
Sixty-one
ETs
resulted in 10 clinical(16.4%) and 8 delivered(13.1%) pregnancies. In cryopreserved-thawed TE group, 1 of the 40 initiated cycles was cancelled before ET. Thirty-nine ETs resulted in 8 clinical(20.5%) and 6 delivered(15.4%) preganancies. The mean
number
of embryos transferred was 1.0 in natural cycle IVF group, 4.2±1.8(1~5) in cryopreserved-thawed ET group, and 4.0±1.1(2~5) in NICE group. there was a significant difference in the clinical preganancy rate per aspiration cycle(p=0.03) and per ET
cycle(p=0.04) between NICE and natural cycle IVF groups. The clinical and delivered pregnancy rates in NICE group were higher than those in cryopreserved-thawed ET group, but there were no statistically significant differences.
In conclusion, as NICE program results in saving the fresh oocyte for the patients participating in cryopreserved-thawed ET, more favorable results might be obtained from NICE cycles in spontaneously ovulatory women who had previously undergone
IVF
with
embryo cryopreservation.
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